Synthesis and Biological Evaluation of Thiazolyl-Ethylidene Hydrazino-Thiazole Derivatives: A Novel Heterocyclic System

The reaction of 2-(1-(2-(2-(4-methoxybenzylidene)hydrazinyl)-4-methylthiazol-5-yl)ethylidene)hydrazinecarbothioamide with a range hydrazonoyl chlorides and α-halo-compounds yielded three new series thiazole derivatives. Chemical physical techniques were used to analyze all newly prepared derivatives (1H-NMR, 13C-NMR, FT-IR mass spectrometry). potential antimicrobial anticancer properties the synthesized investigated using various in vitro biological experiments. Most compounds tested effective against Gram-positive Gram-negative bacteria. In addition, minimum inhibition concentration was determined for antibiotic most active produced substances. cytotoxic activities on HepG-2 (liver carcinoma), HCT-116 (colorectal carcinoma) MDA-MB-231 (breast cell lines comparison cisplatin reference drug colorimetric MTT assay. results detected that compound 10c potent lines. Interestingly, when evaluated their toxicity normal (MRC-5) cells, they exhibited low toxic effects indicating safe use them may require further vivo pharmacological studies.